Urology

Biography:

Abstract:

In recent years, propolis has been the object of extensive research for its antibacterial, anti-oxidant, anti-infl ammatory,\\\\\\\\\\\\\\\\r\\\\\\\\\\\\\\\\nand anti-tumoral activities. Th is study aimed to determine the nephroprotective effi ciency of propolis on experimental\\\\\\\\\\\\\\\\r\\\\\\\\\\\\\\\\nendotoxemic renal damage in rats. In the current study, fi ft y adult Sprague Dawley rats (weighing 200-300 g) were randomly\\\\\\\\\\\\\\\\r\\\\\\\\\\\\\\\\ndivided into fi ve groups of ten rats each. Normal saline solution was administered to the rats in the control group, while in the\\\\\\\\\\\\\\\\r\\\\\\\\\\\\\\\\nsecond group LPS (30 mg/kg), in the third group propolis (250 mg/kg), in the fourth group fi rst propolis and then LPS (30 mg/\\\\\\\\\\\\\\\\r\\\\\\\\\\\\\\\\nkg), and in the fi ft h group, fi rst LPS (30 mg/kg) and then propolis were given. Six hours aft er the application, histopathological\\\\\\\\\\\\\\\\r\\\\\\\\\\\\\\\\nchanges in the kidney tissue samples were determined. Besides, MDA was analyzed as an oxidative stress marker. Th e results demonstrated that the application of propolis prior to LPS administration did not have a signifi cant protective effect against LPS-induced renal damage. In comparison with the kidney sections of rats treated with only LPS, administration of propolis showed a mild but not a signifi cant eff ect against LPS-induced renal damage.