Urology

Biography

Biography: Jacques Choucair

Abstract

Introduction: Prostatitis presents one of the most common entities encountered in urologic practice. Treating ESBL producing enterobacteriaecea urinary tract infections is a major problem especially in prostatitis because of the absence of active transporters for antibiotics and a relatively low prostate penetration of these drugs. Th us, therapeutic options are limited in infections with such resistant bacteria and require the use of carbapenems in the majority of the cases. Ertapenem is used in acute bacterial prostatitis yet not been approved by the FDA for this indication. Th e goal of this study is to compare the effi cacy of ertapenemas to other antibiotics in the treatment of prostatitis with ESBL producing E. coli. Methods: It is a comparative retrospective study of the fi les of patients admitted in Hotel Dieu de France between 1st July 2008 and 1st July 2014 treated for acute bacterial prostatitis caused by E. coli producing ESBL with ertapenem and other antibiotics. Results: Th e mean age of the 110 patients of this study was 69.58 years. Ertapenem was administered without previous effi cient antibiotic treatment in 34 cases. 18.18% recurred in a period of three months. 85% of recurrences were caused by ESBL producing E. coli (15.45%). 17% and 19% of patients treated with meropenem and imipenem respectively recurred in a 3 months period. Conclusion: Ertapenem is as eff ective as other carbapenems in treatment of E. coli producing ESBL and is not associated with a higher recurrence rate.